ESPE Abstracts

Background: Gonadal dysfunction and fertility impairment are some of the many clinical manifestations described among patients with Fanconi anemia (FA). Many who receive hematopoietic stem cell transplantation (HSCT) suffer additionally from infertility due to gonadal damage from their preparative regimen. The effect of HSCT on gonadal insufficiency and fertility potential among children with FA is largely unknown.Methods:</stron...

Background: Bone marrow transplantation (BMT) is known to affect endocrine function, most commonly causing primary hypothyroidism and hypogonadism in children. Newer reduced intensity conditioning (RIC) uses less myeloablative chemotherapy and no irradiation. Our study goal was to evaluate endocrine effects at 1 year post BMT in pediatric patients who received RIC.Methods: Retrospective, IRB-approved chart review was performed on 121 patients (44 females...